Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection

作者：Asquith Christopher R M; Meli Marina L; Konstantinova Lidia S; Laitinen Tuomo; Poso Antti; Rakitin Oleg A; Hofmann Lehmann Regina; Allenspach Karin; Hilton Stephen T^*

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(6): 1352-1355.

DOI：10.1016/j.bmcl.2014.12.047

• FIV
• HIV
• Tetrathiocenes
• Nucleocapsid
• Zinc finger

A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.

• 出版日期2015-3-15