A Sense of Self: RIG-I's Tolerance to Host RNA

作者：Schoggins John W^*

来源：Immunity, 2015, 43(1): 1-2.

DOI：10.1016/j.immuni.2015.06.022

The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.

• 出版日期2015-7-21