Association between Adiponectin Receptor 1 Gene Polymorphism and Insulin Resistance in Chinese Patients with Polycystic Ovary Syndrome

作者：Yang, Zongli; Yang, Xiaojv; Xu, Jine; Sun, Yongmei; Shi, Yuhua; Fang, Shibao^*

来源：Gynecologic and Obstetric Investigation, 2014, 77(1): 45-49.

DOI：10.1159/000356960

• Polycystic ovary syndrome
• Insulin resistance
• Adiponectin receptor 1
• Gene polymorphism

Background/Aims: Adiponectin receptor 1 (ADIPOR1) is an identified receptor for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties. The ADIPOR1 gene is a potential candidate gene in polycystic ovary syndrome (PCOS). The aim of this study is to assess the association between single-nucleotide polymorphism (SNP) rs1539355 in the ADIPOR1 gene and PCOS in Chinese women. Methods: 302 patients with PCOS and 312 healthy controls were included in this study. The ADIPOR1 genotype distribution was detected using the polynnerase chain reaction melting temperature shift method. Results: The genotypic distributions of SNP rs1539355 did not differ in patients with PCOS compared to controls. However, the frequency of the G allele in the PCOS group was significantly higher than that in the control group (p = 0.037). Patients with the AG or GG genotype had a higher homeostasis model assessment for insulin resistance (HOMA-IR) (p < 0.05) compared to patients with the AA genotype. The fasting insulin levels in subjects with the GG genotype were significantly higher than those in patients with the AA genotype (p < 0.05). Conclusion: SNP rs1539355 in the ADIPOR1 gene is associated with insulin resistance in Chinese PCOS patients.

• 出版日期2014
• 单位青岛大学; 山东大学