Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barre syndrome in Northern Indian population

作者：Nyati Kishan Kumar; Prasad Kashi Nath^*; Verma Avantika; Singh Aloukick Kumar; Rizwan Arshi; Sinha Sushmita; Paliwal Vimal Kumar; Pradhan Sunil

来源：Journal of Neuroimmunology, 2010, 218(1-2): 116-119.

DOI：10.1016/j.jneuroim.2009.10.018

• Guillain-Barre syndrome
• TLR4 polymorphism
• Campylobacter jejuni
• Lipopolysaccharide

Molecular mimicry between Campylobacter jejuni lipopolysaccharide and host gangliosides induces an immune response leading to axonal damage and Guillain-Barre syndrome (GBS). TLR polymorphisms are associated with many autoimmune diseases. The role of the TLR4 gene in GBS susceptibility largely remains unknown. We investigated TLR4 polymorphism in GBS. One hundred and twenty GBS patients and 150 healthy controls were included. TLR4 (Asp299Gly and Thr399Ile) genes were studied by PCR-RFLP. TLR4 (Asp299Gly) polymorphism was significantly associated with GBS (p, 0.045; OR, 8.75; 95% CI, 1.05-72.88); only acute motor axonal neuropathy (AMAN) was associated with Gly299Gly homozygote (p, 0.027; OR, 12.40; 95% CI, 1.33-115.77) and Thr399Ile (p, 0.019 OR. 3.42; 95% G, 1.22-9.54) heterozygote, and TLR4399Ile allele (p, 0.045; OR, 2.63; 95% CI, 1.02-6.75) compared to controls. In conclusion, TLR4 (Asp299Gly) polymorphism is associated with an increased susceptibility to GBS. Besides Asp299Gly, AMAN subtype is also associated with Thr399Ile polymorphism.

• 出版日期2010-1-25
• 单位河北医科大学