New potent vinca alkaloids resulting from an unexpected isomerization

作者：Quoc Anh Ngo; Roussi Fanny^*; Thoret Sylviane; Gueritte Francoise

来源：Tetrahedron Letters, 2012, 53(44): 5821-5823.

DOI：10.1016/j.tetlet.2012.07.137

• Vinca alkaloids
• Enammoniums
• Ammonium salts
• Tubulin

Four new vinca alkaloids have been elaborated, using an unexpected isomerization and formation of stable enammoniums in very mild conditions. They are cytotoxic on a sub-micromolar range and inhibit microtubule assembly.

• 出版日期2012-10-31