Promoting the recovery of neurologic function and antagonizing cell apoptosis in ICH model rats by Induced Pluripotent Stem Cell Transplantation

作者：Qi Jing; Qin Jie; Gong Guangming; Song Bo; Zhang Huili; Wang Yanlin; Qi Haiyun; Yang Bo; Zhang Yi; Xu Yuming; Sun Shilei^*

来源：Life Science Journal-Acta Zhengzhou University Overseas Edition, 2013, 10(1): 280-284.

Intracerebral hemorrhage (ICH) is a major disease that seriously threatens human health; it features high fatality rate and disability rate and often leaves severe neurologic dysfunction even after recovery. The effect of induced pluripotentstem cells (iPSCs) transplantation on the recovery of the neurologic dysfunction of ICH is still uncertain. We prepared ICH rat models by injecting collagenase to the striatum of rats through stereotaxic apparatus, injected derived from ICH patients around the hematoma to evaluate the dynamic changes of neurologic function on day 1, 3, 7, 14 and 28 after ICH treatment by iPSCs transplantation with modified neurological severity score (mNSS) table, and studied the cell apoptosis changes around the hematoma. We found out that the neurological scores of rats were obviously improved and the apoptotic cells were significantly reduced compared with the model group. Our research results showed that iPSCs transplantation can effectively promote the recovery of neurologic function of ICH rats and antagonize cell apoptosis induced by encephalorrhagia.

• 出版日期2013
• 单位郑州大学