Multicenter Phase II Study of Nedaplatin and Irinotecan for Patients with Squamous Cell Carcinoma of the Lung: Thoracic Oncology Research Group 0910

作者：Yamada Kouzo; Saito Haruhiro; Kondo Tetsuro; Murakami Shuji; Masuda Noriyuki; Yamamoto Michiko; Igawa Satoshi; Katono Ken; Takiguchi Yuichi; Iwasawa Shunichiro; Kurimoto Ryota; Okamoto Hiroaki; Shimokawa Tsuneo; Hosomi Yukio; Takagi Yusuke; Kishi Kazuma; Ohba Mari; Oshita Fumihiro^*; Watanabe Koshiro

来源：Anticancer Research, 2015, 35(12): 6705-6711.

• nedaplatin
• irinotecan
• squamous cell carcinoma
• lung cancer

Squamous cell carcinoma (SCC) of the lung is moderately responsive to anticancer drugs, but no specific chemotherapy regimens have yet been established. We conducted a multicenter phase II study of nedaplatin (NP) and irinotecan (CPT) for SCC of the lung. Fifty patients underwent 4 to 6 cycles of chemotherapy comprising of NP at 100 mg/m(2) on day 1 and CPT at 60 mg/m(2) on days 1 and 8 every 4 weeks. Twenty-seven patients received 4 to 6 cycles of chemotherapy (median=4 cycles). Major toxicities included neutropenia (46.0%), grade 3 or 4 anorexia (22.0%), febrile neutropenia (16.0%), diarrhea (12.0%), hyponatremia (12.0%), grade 4 anemia (10.0%), thrombocytopenia (10.0%) and infection (10.0%). There were no treatment-related deaths. One patient achieved a complete response and 16 a partial response, with an overall response rate of 34.0%. The median survival time was 11.8 months (95% CI=8.3-15.8 months) and the 2-year survival rate was 22.0%. In conclusion, the NP and CPT regimen is not recommend for further evaluation for patients with advanced SCC of the lung.

• 出版日期2015-12