Arterial stiffness and wave reflection in patients with premature myocardial infarction

作者：Gedikli Omer^*; Kiris Gulhanim; Kahraman Nuray; Hosoglu Yusuf; Kutlu Merih

来源：Experimental and Clinical Cardiology, 2013, 19(1).

• Arterial stiffness
• Premature myocardial infarction
• Wave reflection

BACKGROUND: Young and old patients with myocardial infarction (MI) have different risk factor profiles, clinical presentations and prognoses. Although a relationship between arterial stiffness and coronary artery disease has been established, information regarding arterial stiffness in patients with premature MI is scarce.
OBJECTIVES: The present study investigated arterial stiffness and wave reflections in patients with premature ST-elevation MI.
METHODS: Premature MI was defined as the development of ST-elevation MI in individuals <55 years of age. Arterial stiffness and wave reflections in 32 consecutive patients (mean [+/- SD] age 46 +/- 7 years) with first ST-elevation MI was measured using applanation tonometry (SphygmoCor system, AtCor Medical, Australia). Thirty-four age- (45 +/- 6 years) and sex-matched healthy individuals without a history of MI were enrolled as controls. Aortic pulse wave velocity was measured as index of elastic-type aortic stiffness. The heart rate-corrected aortic augmentation index (AIx@75) was estimated as a marker of wave reflections.
RESULTS: The mean AIx@75 was significantly higher in the premature MI group than controls (20 +/- 9% versus 15 +/- 7.6%%; P=0.02); however, aortic pulse wave velocity was similar between the groups (9 +/- 1.4 m/s versus 9.3 +/- 1.8 m/s; P=0.20). Cigarette smoking and diabetes history was significantly higher in the premature MI group.
CONCLUSION: Results of the present pilot study indicate that increased wave reflections may be among the risk factors for premature ST-elevation MI.

• 出版日期2013