New Strategies in the Prevention of Actinic Keratosis: A Critical Review

作者：Krutmann Jean; Berking Carola; Berneburg Mark; Diepgen Thomas L; Dirschka Thomas; Szeimies Markus

来源：Skin Pharmacology and Physiology, 2015, 28(6): 281-289.

DOI：10.1159/000437272

• Actinic keratosis
• Nonnnelanoma skin cancer
• Photolyase
• Medical device
• Photoprotection
• Photorepair

Actinic keratosis (AK) or lesions of epidermal dysplasia occurring in skin chronically exposed to solar radiation is very prevalent in lighter skin persons, with chronic long-term sun exposure being the major risk factor. With an aging population it is expected that the prevalence of AK will further increase. AK can progress to nonmelanoma skin cancer (NMSC) and is a public health concern. Six leading dermatologists with expertise in AK and NMSC from Germany met to discuss the nature of the disease and the prevention and treatment strategies available to dermatologists today. While cosmetic sunscreen products form an essential element of sun protection strategies, they are not adequate when damage has already been inflicted. Newly developed products of the medical device category offer DNA repair function paired with high sun protection factor (SPF) UV protection. An adjuvant treatment algorithm for various moderate risk, sunscreen only is recommended. For patient groups with high and very high risk, a very high photoprotection and photorepair action (DNA repair enzymes) in medical device products all year round is recommended.

• 出版日期2015