Neuropsychological and Neuroimaging Markers in Early Versus Late-Onset Alzheimer's Disease

作者：Kaiser Natalie C^*; Melrose Rebecca J; Liu Collin; Sultzer David L; Jimenez Elvira; Su Michael; Monserratt Lorena; Mendez Mario F

来源：American Journal of Alzheimer's Disease and Other Dementias, 2012, 27(7): 520-529.

DOI：10.1177/1533317512459798

• early onset
• late onset
• neuropsychology
• Alzheimer's disease
• dementia
• neuroimaging
• FDG-PET

Background: Early-onset Alzheimer's disease (EOAD) has been overshadowed by the more common late-onset AD (LOAD). Yet, the literature indicates EOAD may have less hippocampal-memory presentations and more focal neocortical localization early in the disease. Objective: To evaluate these proposed differences between these 2 forms of AD and to explore what they inform about differences in AD pathophysiology. Methods: In all, 21 patients with EOAD and 24 patients with LOAD matched for disease progression and severity were compared on neurocognitive measures and resting state fluorodeoxy-glucose positron-emission tomography (FDG-PET). Results: Patients with EOAD had worse executive functions with greater hypometabolism in the parietal regions; whereas patients with LOAD had worse confrontation naming and verbal recognition memory with greater hypometabolism in inferior frontotemporal regions. Conclusions: In addition to highlighting significant differences between EOAD and LOAD, these results reveal dissociation between executive deficits in AD and frontal hypometabolism, suggesting early disturbances of the parietal-frontal network in EOAD.

• 出版日期2012-11