A positive correlation between serum amyloid beta levels and depressive symptoms among community-dwelling elderly individuals in Japan

作者：Tsuruga Koji; Sugawara Norio^*; Yasui Furukori Norio; Takahashi Ippei; Tsuchimine Shoko; Kaneda Ayako; Nakaji Shigeyuki; Nakamura Kazuhiko

来源：Neuropsychiatric Disease and Treatment, 2014, 10: 1621-1627.

DOI：10.2147/NDT.567205

• Alzheimer%26apos
• s disease
• depression
• dementia
• Japanese

Background: Amyloid beta (A beta) levels have been associated with an increased risk of Alzheimer%26apos;s disease (AD). As depression is common before the onset of AD, serum A beta levels could be associated with depressive symptoms. The aim of this study was to investigate whether serum A beta levels are associated with depressive symptoms and/or cognitive function in community-dwelling elderly individuals. %26lt;br%26gt;Methods: We examined the association between serum A beta levels and depression among 419 Japanese community-dwelling elderly individuals aged 60 years and over. Subjects were divided into two subgroups: younger elderly between 60 and 69 years old and older elderly over 69 years old. The Mini-Mental State Examination (MMSE) was used to assess cognitive function, and symptoms of depression were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). The ability to perform activities of daily living was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Serum A beta levels were measured with a human amyloid beta enzyme-linked immunosorbent assay kit. %26lt;br%26gt;Results: After controlling for potential confounding variables, a multiple linear regression analysis showed that increased levels of serum A beta 40 and A beta 42 were associated with higher CES-D scores in the older elderly subgroup. Under the same condition, multiple regression showed that serum A beta levels were not associated with MMSE scores among the total subjects, younger elderly, or older elderly. %26lt;br%26gt;Conclusion: Serum A beta levels were associated with depressive symptoms in community-dwelling elderly individuals. The present study indicates the possibility that serum A beta may be involved in the development of late-onset depression.

• 出版日期2014