Welwitindolinone C synthetic studies. Construction of the welwitindolinone carbon skeleton via a transannular nitrone cycloaddition

作者：Freeman David B; Holubec Alexandra A; Weiss Matthew W; Dixon Julie A; Kakefuda Akio; Ohtsuka Masami; Inoue Munenori; Vaswani Rishi G; Ohki Hidenori; Doan Brian D; Reisman Sarah E; Stoltz Brian M; Day Joshua J; Tao Ran N; Dieterich Noah A; Wood John L^*

来源：Tetrahedron, 2010, 66(33): 6647-6655.

DOI：10.1016/j.tet.2010.04.131

• Welwitindolinone
• [3+2] Dipolar cycloaddition
• Rhodium carbenoid
• O-H insertion
• Chloronium-ion semi-pinacol

Described is the construction of the N-methylwelwitindolinone C core via an efficient strategy that employs a sequential rhodium carbenoid-mediated O-H insertion, Claisen rearrangement and transannular [3+2] nitrone cycloaddition.

• 出版日期2010-8-14