Neuroprotective and Anti-Inflammatory Effects of Diphenylheptanes from the Fruits of Amomum tsaoko, a Chinese Spice

作者：Zhang, Tian-Tian; Lu, Chuan-Li; Jiang, Jian-Guo^*

来源：Plant Foods for Human Nutrition, 2016, 71(4): 450-453.

DOI：10.1007/s11130-016-0570-5

• Amomum tsaoko
• Diphenylheptanes
• Neuroprotective effect
• Anti-inflammatory

Two novel diphenylheptanes, 2,3- dihydro-2 - (4' - hydroxy-phenylethyl) - 6 - [(3aEuro(3),4aEuro(3) - dihydroxy-5" - methoxy) phenyl] -4 - pyrone (CG-A) and 4 - dihydro-2 - (4' - hydroxy-phenylmethyl) -6 - [(3",4aEuro(3) - dihydroxy-5aEuro(3) - methoxyphenyl) methylene]-pyran-3, 5 - dione (CG-B), were isolated from the dried fruits of Amomum tsaoko, a commercially important spice. This study was designed to investigate their protective effects against H2O2-induced nerve injury, using PC-12 cells to determine the cell cytotoxicity and cell viability. The inhibitory effect on (nitric oxide) NO production was also determined in (lipopolysaccharide) LPS-stimulated macrophage RAW 264.7 cells. The results showed that CG-A and CG-B displayed significant neuroprotective effect and exhibited anti-inflammatory activity in a dose-dependent manner. These findings suggest that CG-A and CG-B are very important nutritional ingredients responsible for the neuroprotective and anti-inflammatory health benefits of A. tsaoko.

• 出版日期2016-12
• 单位华南理工大学; 中国科学院西双版纳热带植物园