科研之友
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摘要
Background: Recently, protection in shock (hemorrhagic or septic) by physostigmine has been demonstrated. Here, we studied the protective effect of intravenous infusion of physostigmine in a rat model of severe intestinal ischemia-reperfusion (I/R) injury and shock. Materials and methods: Mesenteric I/R was induced in male Wistar rats by occlusion of the superior mesenteric artery (90 min) and subsequent reperfusion (120 min). Physostigmine (30 or 70 mu g/kg) was administered as bolus injection before induction of I/R. One additional group received, subsequent to the bolus of 30-mu g/kg physostigmine, a continuous infusion of 60-mu g/kg physostigmine till the end of the experiment. Results: Physostigmine at a dose of 70 mu g/kg administered before I/R significantly decreased the macroscopically and microscopically visible intestinal damage. In addition to and presumably as a result of this local protective effect, physostigmine prevented shock induced by reperfusion of the ischemically injured intestine. Lower doses (30 mu g/kg) or continuous application of physostigmine were less advantageous. Conclusions: Physostigmine is clearly protective in intestinal I/R injury and shock. However, for this purpose, physostigmine has to be applied at a dose (70 mu g/kg), that is, approximately double the amount of the presently used clinical dose.
- 出版日期2015-4
