An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy

作者：Gulari Mayurachat Ning; Tripathi Anurag; Ghannad Rezaie Mostafa; Chronis Nikos^*

来源：Micromachines, 2014, 5(3): 607-621.

DOI：10.3390/mi5030607

• ball lens
• microscope
• oil immersion lens
• microlens
• stereo microscope
• high resolution imaging
• add-on module
• optofluidics
• microfabrication

We report the development of an add-on, chip-based, optical module-termed the Microfluidic-based Oil-immersion Lenses (mu OIL) chip-which transforms any stereo microscope into a high-resolution, large field of view imaging platform. The mu OIL chip consists of an array of ball mini-lenses that are assembled onto a microfluidic silicon chip. The mini-lenses are made out of high refractive index material (sapphire) and they are half immersed in oil. Those two key features enable submicron resolution and a maximum numerical aperture of similar to 1.2. The mu OIL chip is reusable and easy to operate as it can be placed directly on top of any biological sample. It improves the resolution of a stereo microscope by an order of magnitude without compromising the field of view; therefore, we believe it could become a versatile tool for use in various research studies and clinical applications.

• 出版日期2014-9