Differentiation between phyllodes tumours and fibroadenomas using intravoxel incoherent motion magnetic resonance imaging: comparison with conventional diffusion-weighted imaging

作者：Kawashima Hiroko^*; Miyati Tosiaki; Ohno Naoki; Ohno Masako; Inokuchi Masafumi; Ikeda Hiroko; Gabata Toshifumi

来源：British Journal of Radiology, 2018, 91(1084): 20170687.

DOI：10.1259/bjr.20170687

Objective: To investigate whether the parameters derived from intravoxel incoherent motion (IVIM) MRI could differentiate phyllodes tumours (PTs) from fibroadenomas (FAs) by comparing the apparent diffusion coefficient (ADC) values.
Methods: This retrospective study included 7 FAs, 10 benign PTs (BPTs), 4 borderline PTs, and one malignant Biexponential analyses of IVIM were performed using a 3 T MRI scanner. Quantitative IVIM parameters [pure diffusion coefficient (D), perfusion-related diffusion coefficient (D*), and fraction (f)] were calculated. The ADC was also calculated using monoexponential fitting.
Results: The D and ADC values showed an increasing tendency in the order of FA, BPT, and borderline or malignant PT (BMPT). No significant difference was found in the D value among the three groups. The ADC value of the BMPT group was significantly higher than that of the FA group (p = 0.048). The D* value showed an increasing tendency in the order of BMPT, BPT, and FA, and the D* value of the BMPT group was significantly lower than that of the FA group (p = 0.048).
Conclusion: The D* derived from IVIM and the ADC were helpful for differentiating between FA and BMPT.
Advances in knowledge: IVIM MRI examination showed that the perfusion-related diffusion coefficient is lower in borderline and malignant PTs than in FAs and the opposite is true for the ADC.

• 出版日期2018
• 单位河北医科大学