MicroRNA-146b acts as a potential tumor suppressor in human prostate cancer

作者：Ding, Hai-Yong; Qian, Wei-Qing; Xu, Jun^*

来源：Journal of Buon, 2016, 21(2): 434-443.

• apoptosis
• invasion
• metastasis
• miR-146b
• prostate cancer

Purpose: MicroRNAs (miRs) act as either tumor suppressors oncogenes and are frequently deregulated in cancers. Although downregulation of miR-146b has been reported in various cancers, its role in prostate cancer is totally unknown. @@@ Methods: The miR-146b expression in 18 human prostate cancer lines with case-matched adjacent normal tissues was measured by quantitative RT-PCR. Furthermore, the expression levels of miR-146b in normal prostate and prostate cancer cell lines were assessed. Cell proliferation, apoptosis, migration and invasion assays were performed in overexpressing or knockdown miR-146b cells. @@@ Results: miR-146b expression was significantly reduced in all prostate tumor tissues. Furthermore, miR-146b was significantly decreased in prostate cancer cells as compared to normal prostate cells. Loss-of-function and gain of -function showed that miR-146b induced apoptosis and suppressed cell proliferation, migration and invasion of the prostate cancer cell lines. @@@ Conclusion: Our results demonstrated that miR-146b expression is downregulated in prostate tumor tissues and is a potential tumor suppressor miR, suggesting that miR-146b might be a potential clinical marker and therapeutic target for prevention and treatment of prostate cancer.

• 出版日期2016-3
• 单位复旦大学