A comparison of the toxicity and tolerability of two intraperitoneal chemotherapy regimens for advanced-stage epithelial ovarian cancer

作者：Bouchard Fortier Genevieve; Rosen Bany; Vyarvelska Tryna; Pasetka Mark; Covens Allan; Gien Lilian T; Kupets Rachel; Pulman Katherine; Ferguson Sarah E; Vicus Danielle^*

来源：Gynecologic Oncology, 2016, 140(1): 36-41.

DOI：10.1016/j.ygyno.2015.11.005

• Ovarian cancer
• Intraperitoneal chemotherapy
• Carboplatin
• Cisplatin
• Primary cytoreductive surgery
• Toxicity

Objectives. Randomized controlled trials (RCTs) in optimally cytoreduced epithelial ovarian cancer (EOC) patients have demonstrated an impressive survival benefit of intraperitoneal (IP) platinum over intravenous (IV), but its use has been limited by significant toxicity from cisplatin. The aim of this study was to compare the toxicity and tolerability of IP cisplatin to IP carboplatin in women with optimally cytoreduced EOC.
Methods. Retrospective analysis of 141 women with EOC who underwent optimal surgical cytoreduction followed by IV paditaxel and IP cisplatin or IP carboplatin was performed. Toxicities of the two treatment regimens were compared. As a secondary outcome, overall survival (OS) and progression-free survival (PFS) probabilities were obtained using the Kaplan-Meier estimate; the log-rank test was used to compare survival curves.
Results. Of the 141 patients, 77 (54.6%) received IP cisplatin and 64(45.4%) received IP carboplatin. Eighty-six percent received at least 4 cycles of IP chemotherapy. IP cisplatin was associated with significantly more grade 3 nausea and vomiting (10.4% vs 1.6%, p = 0.033), grade 3 neuropathy (7.8% vs 0%, p = 0.013) and grade 2-3 neutropenia (22.1% vs 9.4%, p = 0.042). No difference in PFS (p = 0.602) or OS (p = 0.107) was found between the groups.
Conclusion. IP chemotherapy had a high completion rate in both groups of patients. IP carboplatin required a less resource intense protocol and was tolerated better than IP cisplatin with less gastrointestinal, neurologic and hematologic toxicities.

• 出版日期2016-1