MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle

作者：del Rosario Ricardo C H^*; Damasco Joseph Ray Clarence G; Aguda Baltazar D^*

来源：Scientific Reports, 2016, 6(1): 32823.

DOI：10.1038/srep32823

The restriction point marks a switch in G1 from growth factor-dependent to growth factor-independent progression of the cell cycle. The proper regulation of this switch is important for normal cell processes; aberrations could result in a number of diseases such as cancer, neurodegenerative disorders, stroke and myocardial infarction. To further understand the regulation of the restriction point, we extended a mathematical model of the Rb-E2F pathway to include members of the microRNA cluster miR-17-92. Our mathematical analysis shows that microRNAs play an essential role in fine-tuning and providing robustness to the switch. We also demonstrate how microRNA regulation can steer cells in or out of cancer states.

• 出版日期2016-9-9