Ubiquitin-specific protease 4 promotes TNF-α-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma

作者：Hou, Xiaozhi; Wang, Lijuan; Zhang, Lei; Pan, Xinliang^*; Zhao, Wei

来源：FEBS LETTERS, 2013, 587(4): 311-316.

DOI：10.1016/j.febslet.2012.12.016

• USP4
• RIP1
• Apoptosis
• Deubiquitination

Head and neck squamous cell carcinoma (HNSCC) is a common type of cancer. Better understanding of molecular aberrations associated with HNSCC might identify new diagnostic and therapeutic strategies for this disease. In this study, we found ubiquitin-specific protease 4 (USP4) was significantly upregulated in HNSCC. USP4 negatively regulates RIP1-mediated NF-kappa B activation and promotes TNF-alpha-induced apoptosis in FaDu cells. USP4 directly interacts with receptor-interacting protein 1 (RIP1) and deubiquitinates K63-linked ubiquitination from RIP1. Therefore, our results indicate that USP4 has tumor suppressor roles in HNSCC and suggest USP4 as a potential therapeutic target for HNSCC. @@@ Structured summary of protein interactions: @@@ RIP1 physically interacts with USP4 by anti tag coimmunoprecipitation (View Interaction: 1, 2,

• 出版日期2013-2-14
• 单位山东大学