A population-based case-control study of aetiological factors associated with vulval lichen sclerosus

作者：Higgins C A^*; Cruickshank M E

来源：Journal of Obstetrics and Gynaecology, 2012, 32(3): 271-275.

DOI：10.3109/01443615.2011.649320

• Aetiology
• anogenital
• autoimmune
• lichen sclerosus
• vulva
• women

We aimed to investigate the association between possible aetiological factors and the risk of developing vulval lichen sclerosus (VLS). A population-based case-control questionnaire study was performed comparing women with a diagnosis of VLS (n = 92), with those attending a general gynaecology clinic with no known anogenital dermatosis (n = 66). After adjustment for confounders, factors associated with VLS included a family history of diabetes mellitus (OR = 7.0, p = 0.012) and previous pelvic surgery (OR = 4.75, p = 0.007). The use of barrier and progesterone only methods of contraception (OR = 0.19, p = 0.045), hormone replacement therapy (OR = 0.209, p = 0.025) or hayfever (OR = 0.18, p = 0.008) appeared to be associated with a reduced risk of VLS. In conclusion, we were unable to confirm many proposed aetiological theories associated with the development of VLS, in particular those associated with autoimmunity.

• 出版日期2012-4