A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin

作者：Kou, Geng; Shi, Jingping; Chen, Lin; Zhang, Dapeng; Hou, Sheng; Zhao, Lei; Fang, Chen; Zheng, Lei; Zhang, Xunming; Liang, Ping; Zhang, Xu; Li, Bohua^*; Guo, Yajun

来源：Cancer Letters, 2010, 299(2): 130-136.

DOI：10.1016/j.canlet.2010.08.011

• Vascular endothelial growth factor
• Osteopontin
• Tumor
• Angiogenesis
• Metastasis

Both vascular endothelial growth factor A (VEGF) and osteopontin (OPN) can directly induce tumor angiogenesis, which is essential for the growth and metastasis of solid tumors. Here we engineered a bispecific antibody (VEGF/OPN-BsAb) using the anti-VEGF-A antibody bevacizumab and the anti-OPN antibody hu1A12. Compared with hu1Al2 alone and bevacizumab alone, VEGF/OPN-BsAb was significantly more effective in inhibiting tumor angiogenesis in a highly metastatic human hepatocellular carcinoma nude mouse model. Further study demonstrated that VEGF/OPN-BsAb could effectively suppress primary tumor growth and metastasis to lungs, suggesting that it might be a promising therapeutic agent for treatment of metastatic cancer.

• 出版日期2010-12-28
• 单位中国人民解放军总医院; 中国人民解放军第二军医大学