A Convenient Synthesis of (1H-Azol-1-yl)piperidines

作者:Shevchuk Nadiia V; Liubchak Kostiantyn; Nazarenko Kostiantyn G; Yurchenko Aleksandr A; Volochnyuk Dmitriy M; Grygorenko Oleksandr O*; Tolmachev Andrey A
来源:Synthesis (Germany), 2012, 44(13): 2041-2048.
DOI:10.1055/s-0031-1291126

摘要

A convenient preparation of 3- and 4-(1H-azol-1-yl)piperidines by arylation of azoles (i.e., pyrazoles, imidazoles, and triazoles) with 3- and 4-bromopyridines and subsequent reduction of the pyridine ring was developed. The method was extended to benzo analogues of the title compounds.

  • 出版日期2012-7