A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive protein (hsCRP) as a marker for insulin resistance

作者：O' Sullivan Eoin P; Ashley David T; Davenport Colin; Penugonda Lakshmi; Kelleher Grainne; Devlin Niamh; Crowley Rachel; O' Shea Paula; Agha Amar; Thompson Chris J; O' Gorman Donal J; Smith Diarmuid^*

来源：Metabolism-Clinical and Experimental, 2013, 62(1): 34-38.

DOI：10.1016/j.metabol.2012.06.005

• HOMA-IR
• Abnormal glucose tolerance
• Diabetes

Objective. Insulin resistance (IR) is associated with low adiponectin and elevated high sensitivity C-reactive protein (hsCRP). Osteoprotegerin (OPG) has been shown to be elevated in type 2 diabetes, but whether it reflects underlying IR is unclear. We aimed to compare the ability of serum OPG with adiponectin and hsCRP to act as a marker for IR in individuals with normal and abnormal glucose tolerance. %26lt;br%26gt;Materials/methods. 115 men underwent a 75 g oral glucose tolerance test. OPG, hsCRP and adiponectin were measured using ELISA. IR was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). %26lt;br%26gt;Results. Men with abnormal glucose tolerance (n=38) were older (58.3 +/- 11.2 vs 47.3 +/- 11.4 years, P%26lt;.001), had higher body mass index (BMI) (31.1 +/- 2.9 vs 27.9 +/- 3.2 kg/m(2), P%26lt;.001) and were more insulin resistant (median (I.Q.) HOMA-IR 5.88 (3.38) vs 1.13 (1.14), P%26lt;.001) than those with normal glucose tolerance (n=77). After adjustment for age and BMI, OPG (6.28 (2.32) vs 5.16 (1.86) pmol/L, P%26lt;.001) and hsCRP (2.07 (5.47) vs 0.78 (1.05) mg/L, P%26lt;.001) were higher and adiponectin (3.02 +/- 1.17 vs 4.78 +/- 2.38 mu g/mL, P%26lt;.001) was lower in those with AGT. After adjustment for age and BMI, adiponectin (r=-0.317, P%26lt;.001) and hsCRP (r=0.318, P%26lt;.001), but not OPG (r=0.126, P=.196) correlated with HOMA-IR. On multiple linear regression analysis, adiponectin and hsCRP but not OPG were independent predictors of HOMA-IR. %26lt;br%26gt;Conclusions. OPG is higher in individuals with abnormal glucose tolerance, but unlike adiponectin and hsCRP, does not correlate with HOMA-IR, suggesting its elevation within this cohort of individuals is due to factors other than insulin resistance.

• 出版日期2013-1