Attenuation of Inflammation in the Gut After Experimental SAH in TLR4 Knockout Mice

作者:齐猛; 杭春华; 史继新; 成惠林; 王汉东; 陈罡; 印红霞
来源:中国医师协会神经外科医师分会第四届全国代表大会.

摘要

Background and Purpose:Gastrointestinal dysfunctions are often observed in patients suffering from subarachnoid hemorrhage.It has been proved that experimental SAH could induce histopathological changes and inflammation response in the gut via NF -κB activation pathway in previous studies.TLR4 which is regarded as an upper regulator of inflammation response could induce NF -κB activation.This study was designed to examine the effects of TLR4 deficiency in the attenuation of SAH - induced gut inflammation...

  • 出版日期2009-5-1
  • 单位中国人民解放军东部战区总医院