Assessment of the American Society of Echocardiography-European Association of Echocardiography guidelines for diastolic function in patients with depressed ejection fraction: an echocardiographic and invasive haemodynamic study

作者：Dokainish Hisham^*; Nguyen John S; Bobek Jaromir; Goswami Rajiv; Lakkis Nasser M

来源：European Journal of Echocardiography, 2011, 12(11): 857-864.

DOI：10.1093/ejechocard/jer157

• Diastolic function
• Heart failure
• Haemodynamics

Aims There is controversy surrounding the accuracy of echo-Doppler variables, including early mitral inflow/mitral annular velocity (E/e'), for estimating left ventricular filling pressure (LVFP) in patients with depressed ejection fraction (EF < 50%).
Methods and results The American Society of Echocardiography-European Association of Echocardiography (ASE-EAE) algorithm for diastolic function in depressed LVEF was retrospectively applied to a database of patients who underwent echocardiography <= 20 min of cardiac catheterization. LV pre-atrial contraction pressure (pre-A) >= 15 mmHg was elevated. Of 62 patients studied, the mean age was 53.6 +/- 10.6 years and the mean LVEF was 27.2 +/- 11.8%. The correlations of E/e' (R = 0.43, P = 0.0005) and E (R = 0.39, P = 0.002) with LV pre-A were modest, compared with pulmonary artery pressure (PAP, R = 0.69, P = 0.0006), E/late mitral (A) velocity (R = 0.52, P < 0.0001), and mitral deceleration time (DT, R = -0.51, P < 0.0001). Using the ASE-ESE algorithm starting with E/A, E, and DT, 54 of 62 patients were accurately classified to predict LV pre-A > 15 or <15 mmHg (sensitivity = 84%, specificity = 80%, area under the curve 0.86, P < 0.001). The 6 of 6 patients with E/A < 1 and E < 50 and the 14 of 15 (93%) patients with E/A > 2 and DT < 150 were correctly classified as having normal and elevated LVFP, respectively, while 34 of 41 (83%) patients with E/A = 1-2 or E/A < 1 and E > 50 cm/s were correctly classified using the addition of E/e' and PAP.
Conclusion This retrospective study shows that in this population with depressed LVEF, no single echo-Doppler variable had high accuracy for predicting LV pre-A >= 15 mmHg. However, the ASE-EAE algorithm using multiple variables predicted LVFP with good accuracy, superior to any single echo-Doppler variable alone.

• 出版日期2011-11