An efficient and convenient synthesis of N-substituted amides under heterogeneous condition using Al(HSO4)(3) via Ritter reaction

作者：Karimian Elnaz; Akhlaghinia Batool^*; Ghodsinia Sara S E

来源：Journal of Chemical Sciences, 2016, 128(3): 429-439.

DOI：10.1007/s12039-016-1036-x

• Aluminum hydrogen sulfate [Al(HSO4)(3)]
• Ritter reaction
• N-substituted amides
• heterogeneous catalyst
• nitriles
• alcohols

An efficient and inexpensive synthesis of N-substituted amides from the reaction of aliphatic and aromatic nitriles with various benzylic alcohols (secondary and tertiary) and tent-butyl alcohol by refluxing nitromethane via the Ritter reaction catalyzed by aluminum hydrogen sulfate [Al(HSO4)(3)] is described. The catalyst which is an air -stable, cost-effective solid acid could be readily recycled by filtration and reused four tunes without any significant loss of its activity.

• 出版日期2016-3