科研之友
微信
新浪微博
Facebook
分享链接
摘要
PURPOSE: To assess whether atrial fibrillation (AF) in heart failure (HF) affects oxygen uptake at anaerobic threshold ((V) over dotO(2) AT) and heart rate (HR) kinetics. METHODS: A total of 15 patients with HF and AF and 18 with HF and sinus rhythm (SR) performed a maximal incremental and 2 constant workload cycle ergometer cardiopulmonary exercise tests (below and above AT, at 25% and 75% of maximal workload, respectively). At constant workload tests, kinetics of (V) over dotO(2) and HR were assessed by calculating time constant (tau). RESULTS: HF patients with AF showed a similar peak (V) over dotO(2) to those with SR (16.7 +/- 4.5 mL/kg/min vs 16.6 +/- 3.9 mL/kg/min). However, (V) over dotO(2) AT (11.3 +/- 2.9 mL/kg/min vs 9.3 +/- 2.8 mL/kg/min; P < .05), peak HR (149 +/- 18.8 bpm vs 116.4 +/- 20.4 bpm; P < .001), HR AT (125.3 +/- 19.1 bpm vs 90.3 +/- 15.5 bpm; P < .001), and HR increase during exercise were greater in HF patients with AF. Finally, tau HR and tau(V) over dotO(2) below and above AT were not significantly different. CONCLUSIONS: In HF patients with AF, despite a similar peak (V) over dotO(2) compared with patients with HF and SR, (V) over dotO(2) AT is higher because of a higher HR and a greater HR increase during exercise. One postulated mechanism would be a greater cardiac output increase at the beginning of exercise in HF patients with AF. The delayed AT generates uncertainty about the meaning of a (V) over dotO(2) value at AT in HF patients with AF, because a higher AT is usually associated with better performance and a better prognosis.
- 出版日期2016-6
