Adherence to antibiotic treatment guidelines and outcomes in the hospitalized elderly with different types of pneumonia

作者：Rossio Raffaella; Franchi Carlotta^*; Ardoino Ilaria; Djade Codjo D; Tettamanti Mauro; Pasina Luca; Salerno Francesco; Marengoni Alessandra; Corrao Salvatore; Marcucci Maura; Peyvandi Flora; Biganzoli Elia M; Nobili Alessandro; Mannucci Pier Mannuccio

来源：European Journal of Internal Medicine, 2015, 26(5): 330-337.

DOI：10.1016/j.ejim.2015.04.002

• Elderly
• Pneumonia
• Antibiotics
• Guidelines adherence
• Mortality
• Re-hospitalization

Background: Few studies evaluated the clinical outcomes of Community Acquired Pneumonia (CAP), Hospital Acquired Pneumonia (HAP) and Health Care-Associated Pneumonia (HCAP) in relation to the adherence of antibiotic treatment to the guidelines of the Infectious Diseases Society of America (IDSA) and the American Thoracic Society (ATS) in hospitalized elderly people (65 years or older).
Methods: Data were obtained from REPOSI, a prospective registry held in 87 Italian internal medicine and geriatric wards. Patients with a diagnosis of pneumonia (ICD-9 480-487) or prescribed with an antibiotic for pneumonia as indication were selected. The empirical antibiotic regimen was defined to be adherent to guidelines if concordant with the treatment regimens recommended by IDSA/ATS for CAP, HAP, and HCAP. Outcomes were assessed by logistic regression models.
Results: A diagnosis of pneumonia was made in 317 patients. Only 38.8% of them received an empirical antibiotic regimen that was adherent to guidelines. However, no significant association was found between adherence to guidelines and outcomes. Having HAP, older age, and higher CIRS severity index were the main factors associated with in-hospital mortality.
Conclusions: The adherence to antibiotic treatment guidelines was poor, particularly for HAP and HCAP, suggesting the need for more adherence to the optimal management of antibiotics in the elderly with pneumonia.

• 出版日期2015-6