Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds

作者：Gorzalczany S^*; Lopez P; Acevedo C; Ferraro G

来源：Journal of Ethnopharmacology, 2011, 133(3): 994-998.

DOI：10.1016/j.jep.2010.11.031

• Lithrea molleoides
• Anacardiaceae
• Anti-inflammatory
• Methyl gallate
• 1,3-Dihydroxy-(Z,Z)-5-(tridec-4 ',7idienyl) benzene
• Carrageenan
• TPA

Aim of the study: In this study the anti-inflammatory activity of aqueous, dichloromethane (CH(2)Cl(2)) and methanolic (MeOH) extracts and two major compounds isolated from Lithrea molleoides (Veil.) Engl. (Anacardiaceae) were evaluated.
Materials and methods: Two classical experimental models were used, carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13 acetate (TPA) induced mouse ear edema.
Results: MeOH extracts exhibited a significant systemical anti-inflammatory effect in the carrageenan (inhibition of 46% at 3 h) and in the TPA-ear edema test (inhibition of 21%). The presence of methyl gallate (inhibition of 63% in TPA ear edema), as one of the main compounds in the active fraction from MeOH extract may be explained the effect observed. Also, 1,3-dihydroxy-(Z,Z)-5-(tridec-4',7idienyl) benzene obtained from CH(2)Cl(2) extract showed a significant topical anti-inflammatory activity (inhibition of 68%). Furthermore, no signs of toxicity were observed with doses up to 3 g/kg in an acute toxicity assay.
Conclusions: The results of this study present evidence that Lithrea molleoides given either systemically or topically has anti-inflammatory properties.

• 出版日期2011-2-16