Decrease Recurrence Rate of Condylomata Acuminata by Photodynamic Therapy Combined with CO2 Laser in Mainland China: A Meta-Analysis

作者：Zhu, Xiaoling; Chen, Hongxiao; Cai, Longfeng; Yu, Zhiming; Cai, Limin^*

来源：Dermatology, 2012, 225(4): 364-370.

DOI：10.1159/000346330

• Photodynamic therapy
• CO2 laser
• Condylomata acuminata
• Recurrence

Background: Condylomata acunninata (CA) are caused by human papillomavirus. Most conventional therapies for CA have high recurrence rate. Objectives: To compare the recurrence rate of 5-aminolaevulinic acid photodynarnic therapy (ALA-PDT) combined with CO2 laser and CO2 laser alone for CA treatment in mainland China. Methods: In this metaanalysis, 2,048 cases of CA from 22 articles were divided into two groups. The treatment group was treated by using ALAPDT combined with CO2 laser, and CO2 laser alone was applied in the control group. The recurrence rate of the two groups was calculated and compared. Results: The recurrence rate was 42.67% (451/1,057) in the control group and 10.29% (102/991) in the treatment group, with a significant statistical difference between the two groups (chi(2) = 271.98, p < 0.0001). Conclusion: ALA-PDT combined with CO2 laser was more effective in decreasing the recurrence rate of CA compared with CO2 laser alone. It might offer a wide clinical application for CA treatment.

• 出版日期2012
• 单位哈尔滨医科大学