A simple and straightforward method for one-pot synthesis of 2,4,5-triarylimidazoles using titanium dioxide as an eco-friendly and recyclable catalyst under solvent-free conditions

作者：Brahmachari Goutam^*; Das Suvankar

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2013, 52(3): 387-393.

• 2,4,5-Triarylimidazoles
• multicomponent reaction
• one-pot synthesis
• titaniun dioxide
• solvent-free
• green method

Titanium dioxide has been found to be a mild and effective catalyst for the straightforward and efficient synthesis of 2,4,5-triarylimidazoles by three-component, one-pot condensation of 1,2-diketones, aryl aldehydes and ammonium acetate under solvent-free conditions. The operational simplicity, good yield of products, and the use of non-toxic, inexpensive and recyclable heterogeneous catalyst makes this environmentally benign three-component one-pot cyclo-condensation reaction as an attractive method.

• 出版日期2013-3