A Selenide-Based Approach to Photochemical Cleavage of Peptide and Protein Backbones at Engineered Backbone Esters

作者：Eastwood Amy L; Blum Angela P; Zacharias Niki M; Dougherty Dennis A^*

来源：Journal of Organic Chemistry, 2009, 74(23): 9241-9244.

DOI：10.1021/jo901368g

A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology Studies of proteins.

• 出版日期2009-12-4