Application of Supramolecular Chemistry on Pharmaceutical Cocrystals

作者：Chen Jia Mei; Wu Chuan Bin; Lu Tong Bu^*

来源：Chemical Journal of Chinese Universities, 2011, 32(9): 1996-2009.

• Supramolecular chemistry
• Pharmaceutical cocrystal
• Hydrogen bond
• Supramolecular synthon

Pharmaceutical cocrystal is a new type of pharmaceutical crystalline state. It is attractive to pharmaceutical scientists because it can provide a number of crystalline states for a given active pharmaceutical ingredient(API), in which the physical and chemical properties of the API can be adjusted by pharmaceutical cocrystal. In this review, we address pharmaceutical coerystals from the perspective of supramolecular chemistry, and present a series of structures of pharmaceutical cocrystals constructed through hydrogen bonding supramolecular synthons, in which the physical and chemical properties(solubility, dissolution, bioavailability, melting point, stability, etc.) of APIs can be changed by pharmaceutical cocrystal.

• 出版日期2011-9-10
• 单位中山大学