An efficient one-pot synthesis of carbazole fused benzoquinolines and pyridocarbazoles

作者：Arya Kripalaya Ratheesh; Sparkes Hazel A; Prasad Karnam Jayaram Pillai Rajendra^*

来源：Journal of Chemical Sciences, 2018, 130(4): UNSP 41.

DOI：10.1007/s12039-018-1428-1

• Modified Friedlander reaction
• benzoquinoline-carbazoles
• pseudo multicomponent reaction
• carbazole substituted pyridocarbazole

A one-pot, solvent-free protocol for the synthesis of chloro-substituted benzoquinoline-carbazole derivatives via a modified Friedlander hetero-annulation reaction between 2, 3, 4, 9-tetrahydrocarbazol-1-one and 3-amino-2-naphthoic acid in the presence of POCl3 is described. In addition, the direct pseudo multicomponent transformation of 2, 3, 4, 9-tetrahydrocarbazol-1-one, malononitrile and 9-ethyl-3-carbazolecarboxaldehyde results in the formation of a multifunctionalized carbazole through a Knoevenagel-Michael addition-cyclization reaction has also been reported. All the newly synthesized molecules were deduced by spectral and analytical methods.

• 出版日期2018-4