Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia

作者：Donneborg M. L.^*; Vandborg P. K.; Hansen B. M.; Rodrigo-Domingo M.; Ebbesen F.

来源：Journal of Perinatology, 2018, 38(2): 154-158.

DOI：10.1038/jp.2017.167

OBJECTIVE: We investigate whether double phototherapy reduces total serum bilirubin concentration faster than single light during intensive phototherapy with high levels of irradiance using light-emitting diodes.
STUDY DESIGN: Eighty-three infants with gestational age. >= 33 weeks and uncomplicated hyperbilirubinemia were randomized to either double (n = 41) or single phototherapy (n = 42) for 24 h. The mean irradiance was 64.8 mu W cm(-2) nm(-1) from above and 39 mu W cm(-2) nm(-1) from below.
RESULTS: The percentage decreases of total serum bilirubin after 12 h of double vs single phototherapy were (mean (95% confidence interval (CI))) 39% (37 to 42) vs 30% (27 to 32), respectively (P < 0.001). After 24 h, the decreases were 58% (56 to 61) vs 47% (44 to 50), respectively (P < 0.001). The results were still significant after adjustment for confounding. The only side effect was loose stools.
CONCLUSION: Even with intensive phototherapy increasing spectral power by increasing the irradiated body surface area, the efficacy of phototherapy is improved.

• 出版日期2018-2