An efficient synthesis of novel bis-triazole glycoconjugates via a three-component condensation as a key reaction

作者：Cheng, Jie^*; Gu, Zhenlong; He, Caiyu; Jin, Jie; Wang, Lijun; Li, Guojun; Sun, Bei; Wang, Hui; Bai, Jun

来源：Carbohydrate Research, 2015, 414: 72-77.

DOI：10.1016/j.carres.2015.07.004

• 1,2,3-Triazole
• 1,3-Dipolar cycloaddition
• Glycoconjugate
• Multicomponent reaction

Novel bis-triazole glycoconjugates were designed and prepared successfully via 5 steps from propargyl per-O-acetyl-beta-D-glucoside or xyloside (total yield of 48-53%), after utilizing a three-component condensation of propargyl per-O-acetyl-beta-D-glycoside, formaldehyde, and sodium azide as a key step to synthesize 2-hydroxymethyl-2H-1,2,3-triazole glycoconjugates. The developed bis-triazole glycoconjugates would be crucial in antivirus pharmacology and chemical biology.

• 出版日期2015-9-23
• 单位安徽大学; 合肥工业大学