Mutations of ras genes are relatively frequent in Japanese prostate cancers: Pointing to genetic differences between populations

作者：Shiraishi T; Muneyuki T; Fukutome K; Ito H; Kotake T; Watanabe M^*; Yatani R

来源：Anticancer Research, 1998, 18(4B): 2789-2792.

• ras gene mutation
• Japanese
• prostate cancer

Point mutations of the ras gene family are thought to be involved in the development of a variety of human tumors. However, it remains unknown whether the ms gene might play a key role in prostate carcinogenesis. We therefore analysed Ki;Nand H-ras gene mutations in a series of 81 Japanese prostate cancers using PCR-SSCP analysis and Mutant-Allele-Specific Amplification (MASA) method Mutated as genes were detected in 20 of the 81 samples (24%); three of 22 latent, one of five stage B, four of 14 stage C and 12 of 40 stage D cancers. Of the twenty as gene mutations 13 were in Ki-ras (codon 12), five in H-ras codon 61 and two H-vas codon 13. The observed frequency of ras gene mutations was higher than that reported in the literature for some non-Japanese prostate cancers, suggesting the possibility of genetic differences between populations.

• 出版日期1998-8