Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: Inhibitors of the neutrophil respiratory burst in a model of gouty arthritis

作者：Pearce A Norrie; Chia Elizabeth W; Berridge Michael V; Clark George R; Harper Jacquie L; Larsen Lesley; Maas Elizabeth W; Page Michael J; Perry Nigel B; Webb Victoria L; Copp Brent R^*

来源：Journal of Natural Products, 2007, 70(6): 936-940.

DOI：10.1021/np060626o

Ascidiathiazones A (3) and B (4), two new tricyclic thiazine-containing quinolinequinone alkaloids, were isolated from the New Zealand ascidian Aplidium species. Both compounds inhibited the in vitro production of superoxide by PMA-stimulated human neutrophils in a dose-dependent manner with IC50 1.55 +/- 0.32 and 0.44 +/- 0.09 mu M, respectively. In vivo inhibition of superoxide production by peritoneal neutrophils in a murine model of gout was observed for both compounds with oral doses of 25.6 mu mol/kg. Ascidiathiazone A (3) was synthesized in four steps from 8-hydroxyquinoline-2-carboxylic acid.

• 出版日期2007-6
• 单位河北医科大学