摘要
A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [Ga-68]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (%26lt;15 min) and removal of organic solvents. The method produces high peptide-bound % (%26gt;97%), and specific activity (%26gt;40 MBq nmole(-1) [Ga-68]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.
- 出版日期2013-6