Dietary fat and early-onset prostate cancer risk

作者：Lophatananon Artitaya^*; Archer Jane; Easton Douglas; Pocock Richard; Dearnaley David; Guy Michelle; Kote Jarai Zsofia; O'Brien Lynne; Wilkinson Rosemary A; Hall Amanda L; Sawyer Emma; Page Elizabeth; Liu Jo Fen; Barratt Sandra; Rahman Aneela A; Eeles Rosalind; Muir Kenneth

来源：British Journal of Nutrition, 2010, 103(9): 1375-1380.

DOI：10.1017/S0007114509993291

• Early-onset prostate cancer
• Total fat
• Fat subtypes
• Case-control studies

The UK incidence of prostate cancer has been increasing in men aged <60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to prostate cancer risk. The aim of the present study was to investigate the role of dietary fat intake and its derivatives on early-onset prostate cancer risk. During 1999-2004, a population-based case-control study with 512 cases and 838 controls was conducted. Cases were diagnosed with prostate cancer when 60 years. Controls were sourced from UK GP practice registers. A self-administered FFQ collected data on typical past diet. A nutritional database was used to calculate daily fat intake. A positive, statistically significant risk estimate for the highest v. lowest quintile of intake of total fat, SFA, MUFA and PUPA was observed when adjusted for confounding variables: OR 2.53 (95% CI 1.72, 3.74), OR 2.49 (95% CI 1.69, 3-66), OR 2-69 (95% CI 1-82, 3.96) and OR 2-34 (95% CI 1.59, 3.46), respectively, with all P for trend <0.001. In conclusion, there was a positive statistically significant association between prostate cancer risk and energy-adjusted intake of total fat and fat subtypes. These results potentially identify a modifiable risk factor for early-onset prostate cancer.

• 出版日期2010-5-14