Hierarchical analysis and multi-scale modelling of rat cortical and trabecular bone

作者：Oftadeh Ramin; Entezari Vahid; Spoerri Guy; Villa Camacho Juan C; Krigbaum Henry; Strawich Elsa; Graham Lila; Rey Christian; Chiu Hank; Mueller Ralph; Hashemi Hamid Nayeb; Vaziri Ashkan; Nazarian Ara^*

来源：Journal of the Royal Society Interface, 2015, 12(106): UNSP 20150070.

DOI：10.1098/rsif.2015.0070

• cortical and trabecular bone
• hierarchical analysis
• continuum micromechanics
• bone mechanical properties
• bone composition and structure

The aim of this study was to explore the hierarchical arrangement of structural properties in cortical and trabecular bone and to determine a mathematical model that accurately predicts the tissue's mechanical properties as a function of these indices. By using a variety of analytical techniques, we were able to characterize the structural and compositional properties of cortical and trabecular bones, as well as to determine the suitable mathematical model to predict the tissue's mechanical properties using a continuum micromechanics approach. Our hierarchical analysis demonstrated that the differences between cortical and trabecular bone reside mainly at the micro- and ultrastructural levels. By gaining a better appreciation of the similarities and differences between the two bone types, we would be able to provide a better assessment and understanding of their individual roles, as well as their contribution to bone health overall.

• 出版日期2015-5-6
• 单位东北大学