A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells

作者：Peng Zuo fu; Lan Lin xiang; Zhao Fang; Li Jing; Tan Qiang; Yin Han wei; Zeng Hui hui^*

来源：Journal of Zhejiang University-Science B(Biomedicine & Biotechnology), 2008, 9(1): 16-21.

DOI：10.1631/jzus.B071605

• thioredoxin reductase (TrxR)
• novel TrxR inhibitor
• 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE)
• apoptosis

Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich's ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.

• 出版日期2008-1
• 单位北京大学