ADAPTIVE SEQUENTIAL TESTING FOR MULTIPLE COMPARISONS

作者：Gao Ping^*; Liu Lingyun; Mehta Cyrus

来源：Journal of Biopharmaceutical Statistics, 2014, 24(5): 1035-1058.

DOI：10.1080/10543406.2014.931409

• Adaptive sequential testing
• Exact type I error control
• Markov process
• Multiple comparisons
• Transition density function

We propose a Markov process theory-based adaptive sequential testing procedure for multiple comparisons. The procedure can be used for confirmative trials involving multi-comparisons, including dose selection or population enrichment. Dose or subpopulation selection and sample size modification can be made at any interim analysis. Type I error control is exact.

• 出版日期2014