Alkaloids from the roots of Zanthoxylum nitidum and their antiviral and antifungal effects

作者:Yang Guohong; Chen Daofeng
来源:Chemistry and Biodiversity, 2008, 5(9): 1718-1722.
DOI:10.1002/cbdv.200890160

摘要

Five alkaloids, 5,6-dihydro-6-methodynitidine (1), dictamnine (2), gamma-fagarine (3), skimmianine (4). and 5-methoxydictamnine (5). were isolated from the roots of Zanthoxylum nitidum. Their structures and configurations were elucidated by spectroscopic methods and X-ray analysis. Compounds 1, 4, and 5 showed in vitro antiviral effect against hepatitis B virus, and compounds 2, 3, and 5 demonstrated marked antimitotic and antifungal activity.