Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels

作者：Chemin J; Girard C; Duprat F; Lesage F; Romey G; Lazdunski M^*

来源：The EMBO Journal, 2003, 22(20): 5403-5411.

DOI：10.1093/emboj/cdg528

• diacylglycerol
• glutamate
• IP3
• phosphatidic acid
• PIP2

Group I metabotropic glutamate receptors (mGluRs) are implicated in diverse processes such as learning, memory, epilepsy, pain and neuronal death. By inhibiting background K+ channels, group I mGluRs mediate slow and long-lasting excitation. The main neuronal representatives of this K+ channel family (K-2P or KCNK) are TASK and TREK. Here, we show that in cerebellar granule cells and in heterologous expression systems, activation of group I mGluRs inhibits TASK and TREK channels. d-myo-inositol-1,4,5-triphosphate and phosphatidyl-4,5-inositol-biphosphate depletion are involved in TASK channel inhibition, whereas diacylglycerols and phosphatidic acids directly inhibit TREK channels. Mechanisms described here with group I mGluRs will also probably stand for many other receptors of hormones and neurotransmitters.

• 出版日期2003-10-15