Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis

作者：Yao Yibing; Fan Yu; Wu Jun; Wan Haisu; Wang Jing; Lam Stephen; Lam Wan L; Girard Luc; Gazdar Adi F; Wu Zhihao^*; Zhou Qinghua

来源：Biochemical and Biophysical Research Communications, 2012, 423(3): 613-619.

DOI：10.1016/j.bbrc.2012.06.050

• NSCLC
• Tumor-associated autoantibodies
• SEREX
• Early diagnosis

To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.

• 出版日期2012-7-6
• 单位天津医科大学