A quantitative analysis of H-1-MR spectroscopy at 3.0T of three brain regions from childhood to middle age

作者：Yang, Z-Y; Yue, Q.; Xing, H-Y; Tan, Q-Y; Sun, H-Q; Gong, Q-Y; Tan, Z-J; Quan, H.^*

来源：British Journal of Radiology, 2015, 88(1052): 20140693.

DOI：10.1259/bjr.20140693

• MAGNETIC-RESONANCE-SPECTROSCOPY
• PROTON MR SPECTROSCOPY
• NORMAL AGING BRAIN
• WHITE-MATTER
• METABOLIC-CHANGES
• HIPPOCAMPUS
• ORGANIZATION
• GLUTAMATE
• VOLUMES
• GRAY

Objective: To study age-related metabolic changes in different brain regions.
Methods: Point-resolved spectroscopy (repetition time/echo time=2000ms/30ms) was performed in the left and right hippocampus, the left thalamus and the left centrum semiovale of 80 healthy subjects (37 females and 43 males aged 7-64 years). Analysis of covariance and linear regression were used for statistical analysis. Both metabolite concentration ratios with respect to total creatine (tCr) and absolute metabolite concentrations were included for analysis.
Results: Ins (myo-inositol)/tCr (p<0.001) and absolute Ins concentration (p=0.031) were significantly increased with age after adolescence. NAA (N-acetylaspartic acid)/tCr (p<0.001) and absolute NAA concentration (p=0.010) significantly declined with age after adolescence.
Conclusion: Age-related increase of Ins and decline of NAA are found in all three regions, especially at the hippocampus, indicating possible gliosis in the ageing brain.
Advances in knowledge: We could use NAA/tCr and Ins/tCr as an indicator to estimate the neurons-to-glial cells ratio at the thalamus. This may be an index to distinguish normal tissues from gliosis.

• 出版日期2015
• 单位华中科技大学; 武汉大学