New 1-hydroxy-2-thiopyridine derivatives active against both replicating and dormant Mycobacterium tuberculosis

作者：Salina Elena G^*; Ryabova Olga; Vocat Anthony; Nikonenko Boris; Cole Stewart T; Makarov Vadim

来源：Journal of Infection and Chemotherapy, 2017, 23(11): 794-797.

DOI：10.1016/j.jiac.2017.04.012

• Mycobacterium tuberculosis
• Antitubercular activity
• Dormancy
• Latent tuberculosis
• New drugs

Tuberculosis (TB) treatment is confounded by the range of metabolic states displayed by Mycobacterium tuberculosis, by the long duration required and by the increasing prevalence of drug-resistant strains. Latent TB infection is especially difficult to treat due to the phenotypic antibiotic resistance of non-replicating M. tuberculosis. Therefore, the development of new drugs effective against both active and latent TB infection is needed. New 1-hydroxy-2-thiopyridine derivatives were synthesized and found to be highly effective in vitro against both actively growing and dormant non-culturable M. tuberculosis. Such compounds are leads for the development of new drugs for all forms of TB including latent infection.

• 出版日期2017-11