A novel appetite peptide, nesfatin-1 in patients with non-alcoholic fatty liver disease

作者：Basar Omer^*; Akbal Erdem; Koklu Seyfettin; Kocak Erdem; Tuna Yasar; Ekiz Fuat; Gultuna Selcan; Yilmaz Fatma Meric; Aydogan Temucin

来源：SCANDINAVIAN JOURNAL OF CLINICAL %26 LABORATORY INVESTIGATION, 2012, 72(6): 479-483.

DOI：10.3109/00365513.2012.699097

• Nesfatin-1
• non-alcoholic fatty liver disease
• appetite
• liver enzymes
• obesity

Background and aims. Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver pathology worldwide and is strongly associated with obesity and insulin-resistance and food intake. Nesfatin-1 is a new peptide that controls appetite and food intake. The objective of this research was to examine the serum concentrations of nesfatin-1 in NAFLD. Material and methods. Thirty NAFLD patients who had elevated liver enzymes and 40 age-and sex-matched healthy subjects were included in this study. NAFLD was diagnosed and graded with the findings of liver ultrasound scan. Nesfatin-1 concentrations were measured using an ELISA method and the relationship between nesfatin-1 and metabolic parameters were investigated. The subjects were divided into two groups according to their body mass index (%26gt;= 30 and %26lt; 30) and nesfatin-1 concentrations were examined between both groups. Results. Serum nesfatin-1 concentrations in NAFLD patients were lower than healthy controls (0.26 +/- 0.14 ng/ml, 0.38 +/- 0.18 ng/ml, respectively, and p = 0.008). We found a negative correlation between nesfatin-1 and fasting glucose and body mass index. In obese subjects, serum nesfatin-1 concentrations were significantly lower when compared with non-obese subjects (0.26 +/- 0.12 ng/ml, 0.37 +/- 0.19 ng/ml, respectively; p = 0.014). In addition, we showed that nesfatin-1 concentrations in subjects with insulin resistance were significantly lower in comparison with insulin-sensitive ones (0.27 +/- 0.17 ng/ml, 0.38 +/- 0.17 ng/ml, respectively; p = 0.015). Conclusion. Our study has shown that nesfatin-1 concentrations were reduced in NAFLD. The results of this study indicate that nesfatin-1 may have a significant role in NAFLD.

• 出版日期2012-10